AngioDynamics NanoKnife is the first surgical ablation system based on Irreversible Electroporation (IRE) technology and represents the next generation in focal ablative therapy.

IRE is a technique using non-thermal energy to create permanent nanopores in the cell membrane to disrupt cellular homeostasis.

The disruption of cellular homeostasis initiates an apoptotic-like effect, which leads to permanent cell death. Unlike thermal modalities, zones of IRE ablation are not deformed or decreased by proximity to blood vessels.

The NanoKnife System reimagines localised therapy through its unique mechanism of action, improving precision, expanding versatility, and increasing preservation.

Key Features

• Non-thermal ablation: The NanoKnife System uses irreversible electroporation (IRE) to create permanent pores in cell membranes and destroy targeted tissue without the use of thermal energy.
• Customisable treatment zones: Multiple electrode configurations let clinicians shape the ablation zone and plan precise treatment margins.
• Real-time visualisation: The IRE ablation zone can be visualised using real-time ultrasound during the procedure.
• Anatomy-adapted treatment: Electrodes can be configured for different treatment areas, including those near vital structures.
• Preservation of tissue architecture: As a non-thermal modality, IRE can preserve the extracellular matrix and structural framework within the treated area.
• Familiar clinical skills: Treatment draws on image-guided needle placement and biopsy skills used in clinical practice.
• Future treatment planning: Clinicians can consider repeat ablation or subsequent treatments as part of an individual patient’s care plan.